26 research outputs found
Methods to enhance content distribution for very large scale online communities
The Internet has experienced an exponential growth in the last years, and its number of users far from decay keeps on growing. Popular Web 2.0 services such as Facebook, YouTube or Twitter among others sum millions of users and employ vast infrastructures deployed worldwide. The size of these infrastructures is getting huge in order to support such a massive number of users. This increment of the infrastructure size has brought new problems regarding scalability, power consumption, cooling, hardware lifetime, underutilization, investment recovery, etc. Owning this kind of infrastructures is not always affordable nor convenient. This could be a major handicap for starting projects with a humble budget whose success is based on reaching a large audience. However, current technologies might permit to deploy vast infrastructures reducing their cost. We refer to peer-to-peer networks and cloud computing. Peer-to-peer systems permit users to yield their own resources to distributed infrastructures. These systems have demonstrated to be a valuable choice capable of distributing vast amounts of data to large audiences with a minimal starting infrastructure. Nevertheless, aspects such as content availability cannot be controlled in these systems, whereas classic server infrastructures can improve this aspect. In the recent time, the cloud has been revealed as a promising paradigm for hosting horizontally scalable Web systems. The cloud offers elastic capabilities that permit to save costs by adapting the number of resources to the incoming demand. Additionally, the cloud makes accessible a vast amount of resources that may be employed on peak workloads. However, how to determine the amount of resources to use remains a challenge. In this thesis, we describe a hierarchical architecture that combines both: peer-to-peer and elastic server infrastructures in order to enhance content distribution. The peer-topeer infrastructure brings a scalable solution that reduces the workload in the servers, while the server infrastructure assures availability and reduces costs varying its size when necessary. We propose a distributed collaborative caching infrastructure that employs a clusterbased locality-aware self-organizing P2P system. This system, leverages collaborative data classification in order to improve content locality. Our evaluation demonstrates that incrementing data locality permits to improve data search while reducing traffic. We explore the utilization of elastic server infrastructures addressing three issues: system sizing, data grouping and content distribution. We propose novel multi-model techniques for hierarchical workload prediction. These predictions are employed to determine the system size and request distribution policies. Additionally, we propose novel techniques for adaptive control that permit to identify inaccurate models and redefine them. Our evaluation using traces extracted from real systems indicate that the utilization of a hierarchy of multiple models increases prediction accuracy. This hierarchy in conjunction with our adaptive control techniques increments the accuracy during unexpected workload variations. Finally, we demonstrate that locality-aware request distribution policies can take advantage of prediction models to adequate content distribution independently of the system size
NESS. Sistema de recirculaciĂłn de agua caliente sin ramal adicional de retorno. Ahorro de agua y energĂa
El objetivo del presente estudio es identificar las diferencias existentes entre el sistema de aprovechamiento de agua basado en el doble ramal de agua caliente y una innovadora alternativa que realiza la recirculaciĂłn sin la necesidad de un ramal de retorno adicional, empleando la instalaciĂłn convencional de cualquier vivienda. Para ello, se realizarĂĄ un detallado anĂĄlisis del consumo de energĂa y econĂłmico proporcionado por la ya conocida red de retorno con doble ramal de agua caliente, para posteriormente compararlo con el sistema de recirculaciĂłn sin ramal adicional de retorno. Atendiendo a los datos arrojados por esta comparaciĂłn, se presentan las ventajas e inconvenientes de un sistema respecto al otro, y por tanto, cuĂĄl es considerado Ăłptimo en cada caso.Consejo General de la Arquitectura TĂ©cnica de Españ
EducaFarma 3.0. ContinuaciĂłn y mejora de un programa de formaciĂłn continuada de profesores y alumnos de la Facultad de Farmacia con recursos propios
Memoria ID-0186. Ayudas de la Universidad de Salamanca para la innovaciĂłn docente, curso 2014-2015
Influence of non-osteoporotic treatments in patients on active anti-osteoporotic therapy: evidence from the OSTEOMED registry
ProducciĂłn CientĂficaPurpose To evaluate the effect of different non-osteoporotic drugs on the increase or decrease in the risk of incident fragility
fractures (vertebral, humerus or hip) in a cohort of patients diagnosed with osteoporosis on active anti-osteoporotic therapy.
Methods For this retrospective longitudinal study, baseline and follow-up data on prescribed non-osteoporotic treatments
and the occurrence of vertebral, humerus or hip fractures in 993 patients from the OSTEOMED registry were analyzed
using logistic regression models. The drugs evaluated with a possible beneficial effect were thiazides and statins, while the
drugs evaluated with a possible harmful effect were antiandrogens, aromatase inhibitors, proton pump inhibitors, selective
serotonin reuptake inhibitors, benzodiazepines, GnRH agonists, thyroid hormones, and oral and inhaled corticosteroids.
Results Logistic regression analyses indicated that no treatment significantly improved fracture risk, with the only treatments
that significantly worsened fracture risk being letrozole (OR = 0.18, p-value = 0.03) and oral corticosteroids at doses †5 mg/
day (OR = 0.16, p-value = 0.03) and > 5 mg/day (OR = 0.27, p-value = 0.04).
Conclusion The potential beneficial or detrimental effects of the different drugs evaluated on fracture risk are masked by
treatment with anabolic or antiresorptive drugs that have a more potent action on bone metabolism, with two exceptions:
letrozole and oral corticosteroids. These findings may have important clinical implications, as patients receiving these treat-
ments are not fully protected by bisphosphonates, which may imply the need for more potent anti-osteoporotic drugs such
as denosumab or teriparatide.PublicaciĂłn en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y LeĂłn (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEĂN, ActuaciĂłn:20007-CL - Apoyo Consorcio BUCL
El proceso penal del siglo XXI, Quo vadis iustitia?
Actas de la Jornada "EL PROCESO PENAL DEL SIGLO XXI: QUO VADIS IUSTITIA?", celebrada en la Facultad de Derecho de Jerez de la Frontera, de la Universidad de CĂĄdiz, el 24 de Abril de 2015.Quo vadis iustitia? La pregunta persigue que tanta reforma
como se persigue se detenga un momento para responder y, con ello, para
pensar sobre el modelo de justicia que se estå diseñando. Ya han sido muchas
las voces que han hablado de la legislaciĂłn âgalopanteâ o âmotorizadaâ, o que
han usado variados calificativos para referirse al frenesĂ en la productividad de
nuestras cĂĄmaras legislativas. Si esto es algo que puede llegar a provocar
inseguridad jurĂdica, debemos pensar que, cuando de lo que se trata es de las
normas que afectan a la justicia (orgĂĄnicas y procesales) lo que se puede llegar
a provocar es una alteraciĂłn en el equilibrio de los poderes del Estado. No se
puede dejar de lado que el funcionamiento de la justicia tiene que ver con uno
de los poderes del Estado, el cual, precisamente, debe constituir el fiel que
refleje el equilibrio entre los demås, aunque Montesquieu ya no esté muy de
moda.
La jornada s centra en algunos aspectos
de la reforma del proceso penal.Ărea de Derecho Procesal, Facultad de Derecho Universidad de CĂĄdiz
Casa de Iberoamérica (Ayunatmiento de Cådiz)
Gestiona: FUECA
Proyecto InvestigaciĂłn MINECO DER 2011-26954Documento PDF con 232 pĂĄginas
EducaFarma 4.0
Memoria ID-0264. Ayudas de la Universidad de Salamanca para la innovaciĂłn docente, curso 2015-2016
Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism
Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio
¿Qué queda de m�
Este libro es una reclamacioÌn a quienes hemos sido, somos o seremos docentes. A quienes no hemos respetado a las personas que se han puesto junto a nosotros y nosotras, confiando su bien maÌs preciado: la libertad. Estas paÌginas denuncian cada vez que convertimos una visioÌn en la visioÌn, una emocioÌn en la emocioÌn, un saber en el saber, un comportamiento en el comportamiento. Es un grito contra la imposicioÌn, la normalizacioÌn, la neutralizacioÌn y la universalizacioÌn de una perspectiva particular. Una pugna contra cada proceso que no se ha conectado con las vidas de los aprendices.
Un texto colaborativo realizado por alumnado de EducacioÌn y Cambio Social en el Grado en EducacioÌn Infantil de la Universidad de MaÌlaga y coordinado por Ignacio CalderoÌn Almendros
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat